AIM To analyze the relationship between plasma asprosin levels and coronary heart disease (CHD).
METHODS The present investigation collected 281 patients who underwent coronary angiography (CAG) examination in our department from February 2016 to December 2018, According to CAG results, 281patients were divided into a normal control group (n=90), a stable angina pectoris group (n=80), and an acute coronary syndrome group (n=111). Relevant clinical datas were collected for statistical analysis.
RESULTS The levels of HDL, apolipoprotein A1 and asprosin in the ACS and SAP group were lower than those in the normal control group (P < 0.01), These factors were also significantly lower in the ACS group than in the SAP group (HDL-C P < 0.05, the other indicators P < 0.01). Smoking rate, male rate, diabetes rate, lipoprotein (a), apolipoprotein B, HbA1c, CRP and Hcy level in ACS and SAP group were higher than those in the normal control group, (LPa, HbA1C P < 0.05, the other indicators P < 0.01), these factors were also significantly higher in the ACS group than in the SAP group (APoA1, APoB, HbA1C, Hcy P < 0.05, the other indicators P < 0.01). Binary Logistic regression analysis showed that plasma asprosin levels and HDL-C were negatively correlated with CHD (P < 0.01), Smoking rate, CRP and Hcy level were positively correlated with CHD and were independent risk factors for CHD (Smoking rate P < 0.05, the other indicators P < 0.01). However, male, diabetes rate, apolipoprotein A1, apolipoprotein B, and lipoprotein (a) had no significant correlation with CHD.
CONCLUSION Plasma asprosin level is an independent correlative factor of CHD, and negatively correlated with CHD.
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