AIM To compare the effects of levosimendan and milrinone on hemodynamic parameters in patients with acute ejection of fractional heart failure (HFrEF).
METHODS A total of 122 patients with HFrEF who were admitted to the Department of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region from October 2017 to November 2018 were randomly divided into the left Xidandan group (66 cases) and the milrinone group (56 cases). On the basis of the conventional heart failure guidelines, the left heart or the milrinone was used to monitor the heart index (CI) at different time points using Pulse Index Continuous cardiac output (PICCO) monitoring. Hemodynamic parameters such as intrathoracic blood volume index (ITBVI), global end-diastolic volume index (GEDVI), and extravascular lung water index (EVLWI) were compared and analyzed.
RESULTS There was no significant difference in the balance test between age, gender and left ventricular ejection fraction (LVEF) between the left Xidandan group and the milrinone group,0 h between the left Xidandan group and the milrinone group. There were no significant differences in CI, GEDVI, ITBVI, and EVLWI. The left-western group of CI, GEDVI, ITBVI, and EVLWI were at 0 h, 3 h, 8 h, 24 h. The difference between the two groups was statistically significant (P < 0.01). There was no statistically significant difference between the 0 (h) and ITBVI in the milrinone group except 0 h and 3 h), CI, GEDVI, ITBVI, EVLWI results were statistically significant in the other time periods (P < 0.01); left Ximendan group and milrinone group CI, EVLEI at 0 h and There were no significant differences between 3 h, 8 h and 24 h. There was no significant difference in ITBVI and GEDVI except 0 h, and the other time points were statistically significant (P < 0.05, P < 0.01).
CONCLUSION Both the levosimendan group and the milrinone group can improve hemodynamics. The improvement effect is different in different time periods. The PICCO monitoring can effectively evaluate the changes of hemodynamic parameters and assist in the evaluation of clinical treatment decisions.
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