Role of calcium sensing receptors in cardiovascular physiology and disease

Calcium sensing receptor (CaSR), a member of the G protein coupled receptor (GPCRs) C family, can be activated by Ca²⁺ Mg²⁺, amino acids, and polyamines. It is now recognized as an ubiquitously expressed receptor and is highly expressed in the parathyroid gland, kidneys, intestinal system, and skeletal system. It also plays different roles in different tissues of the cardiovascular system and participates in physiological and pathological processes of the cardiovascular system. The focus of this review is to summarize the importance of CaSR in the cardiovascular system.