AIM To explore the relationship between serum uric acid (SUA) level and prognosis of patients with chronic heart failure (CHF) after revascularization.
METHODS 150 CHF patients who completed percutaneous coronary intervention (PCI) or coronary artery bypass graft(CABG) during their hospitalization in the department of cardiology of Jining first people's hospital from August 2016 to August 2017 were selected, according to SUA level, they. were divided into hyperuricemia group and normal uric acid group. Some indexes were observed to analyze the correlation between serum uric acid level and the prognosis of CHF patients. At the same time, part of hyperuricemia patients were selected for uric acid treatment, and the differences of clinical data between different groups were analyzed after 6 months of treatment..
RESULTS ①Multivariate logistic regression was used to evaluate the occurrence of end-point events in heart failure. The results showed that hyperuricemia alone was an independent predictor of poor prognosis, OR=2.19, 95%CI (1.54-4.02), P<0.01.②SUA level was positively correlated with Nt-Probnp (r=0.982, P<0.01), and negatively correlated with LVEF (r=−0.573, P<0.01).③After 6 months of uric acid lowering treatment, the incidence of endpoint events was significantly lower than that of the control group, and the difference was statistically significant (P<0.05).
CONCLUSION SUA level is an independent predictor of complex endpoint events in CHF patients after blood transport reconstruction, and the incidence rate of composite endpoint events in SUA treatment is significantly reduced, which is expected to become a new method to improve the prognosis of elderly CHF patients.
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