AIM To investigate the effects of intravenous anesthesia using different concentrations of sevoflurane on MMSE scores and Ramsay sedation scores in patients undergoing off-pump coronary artery bypass surgery.
METHODS Ninety patients (ASA II or III, aged 56 to 73 years) undergoing off-pump coronary artery bypass grafting surgery were randomly divided into three groups (n = 30, each group): sufentanil + propofol group (Group A), sufentanil + propofol + 0.5 MAC sevoflurane group (Group B) and sufentanil and propofol + 1.0 MAC sevoflurane group (Group C). MMSE scores were recorded respectively 1 day before and 1, 3 and 5 days after operation. Ramsay scores were recorded respectively before and 6 h, 12 h and 24 h after anesthesia.
RESULTS Compared with those before operation, MMSE scores were significantly lower at 1 day and 3 days after operation in all three groups (P<0.05). Compared with those in Group A, MMSE scores in Group B and Group C were significantly higher 1 day and 3 days after operation. Ramsay scores were significantly higher 6 h and 12 h after operation in all three groups (P<0.05).
CONCLUSION Anesthesia with propofol or sevoflurane achieves good sedation, but sevoflurane lowers the risks of postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting surgery.
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