The correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance

  AIM   To study risk factors of patients with premature coronary heart disease and to investigate the correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance.

  METHODS   93 patients underwent coronary angiography were divided into premature coronary heart disease group (n=63) and a control group (coronary artery stenosis <50%, n=30). The Lp-PLA2 levels were investigated between the two groups and the relationship of Lp-PLA2 with risk of patients was studied.

  RESULTS   Lp-PLA2 levels were significantly higher in premature coronary heart disease group than in the control group(P<0.05). Lp-PLA2 had a significant correlation with Gensini score (r=0.368,P<0.05) and GRACE risk score (r=0.402,P<0.05). Multivariate logistic regression analysis showed that Lp-PLA2 was independently associated with premature coronary heart disease (P<0.05).

  CONCLUSION   Lp-PLA2 is independently associated with premature coronary heart disease and positively related with the severity of coronary artery and prognosis. Thus Lp-PLA2 can be used as a predictor of risk assessment in premature coronary heart disease patients.