AIM AIM To explore the factors of pericardial effusion in patients with STEMI, and to evaluate the prognosis of these patients.
METHODS Patients with STEMI, a total of 274 cases, who had received coronary artery intervention treatment, and according to the pericardial effusion, they were divided into a pericardial effusion group (n=55) and nonpericardial effusion group (n=219). Clinical characteristics, related factors, and clinical prognosis in the two groups were observed.
RESULTS There were significant differences between the two groups in age (P<0.01). But sex, hypertension, diabetes, hyperlipidemia, smoking, drinking, family history of coronary heart disease (CHD) demmonstrated no statistical difference. There was a differences when comparing time of the patients in the two groups in which the open culprit artery was prolonged (P<0.01), CK-MB peak was higher (P<0.01), left ventricular ejection fraction (LVEF) of PCI postoperative was lower (P<0.01), ratio of heart function Killip≥grade Ⅲ was higher (P<0.01), ratio of TIMI flow grade 2 of PCI postoperative was higher (P<0.01), ratio of thrombus aspiration and using GPⅡb /Ⅲa receptors inhibitors were lower (P<0.01,P<0.05), ratio of patients with the lesion of LAD was higher (P<0.05), average hospitalization days was extended (P<0.01), incidence rate of severe heart failure and malignant arrhythmia were higher while hospitalized (P<0.05). There was no statistical difference in the TIMI flow grade of PCI preoperative and lesion of LCX between the two groups. Incidence rate of MACE after 6 months in both groups showed the pericardial effusion group with high proportion of severe heart failure and rehospitalization related to heart disease (P<0.05), while malignant arrhythmia, target vessel revascularization, cardiac death, postinfarction mechanical complications, non-lethal myocardial infarction, angina pectoris after myocardial infarction were similar. Multiple logistic aggression analysis was performed to assess predictive factors associated with the occurrence of PE complicating STEMI. The results showed that age, reperfusion therapy time, using GPI, thrombus aspiration CK-MB peak, and TIMI flow grade of PCI postoperative were independent factors.
CONCLUSION Relative factors of pericardial effusion in patients with acute ST-segment elevation myocardial infarction were age, reperfusion therapy time, CK-MB peak, using GPI, thrombus aspiration and TIMI flow grade of PCI postoperative. The clinical prognosis of patients with pericardial effusion in patients with acute ST-segment elevation myocardial infarction was poorer.
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