Correlation of serum uric acid and the prognosis of patients with chronic heart failure and its predictive value

  AIM  To assess correlation between serum uric acid (UA) and prognosis in patients with congestive heart failure (CHF) and its predictive value.

  METHODS  60 patients with CHF were divided into a cardiovascular event group (n = 21) and a non-cardiovascular event group (n = 39) based on the major adverse cardiovascular events during one-year follow up. The correlation between UA and the prognosis of patients with CHF were analyzed, and the preliminary evaluation using ROC curve for predictive value of prognosis.

  RESULTS  The level of UA in events group and non-event group were 486 ± 70 μmol/L and 338 + 86 μmol/L (P < 0.01). Compared with non-event group, levels of left ventricular end-diastolic diameter (LVEDD), left atrial diameter (LAD) and incidence of atrial fibrillation were increase asignificantly, left ventricular ejection fraction (LVEF) decreased significantly (P < 0.01). Multiple Factors analysis showed that UA was an independent factor associated with the prognosis of patients with CHF. Pearson correlation analysis showed that the levels of UA were positively correlated with age, urea nitrogen, creatinine, NT-proBNP and adverse cardiovascular events. (r = 0.12、0.26、0.21、0.24、0.31, all P < 0.01), and negatively correlated with LVEF (r = −0.56, P < 0.01). At the optimum cutoff point of 445 μmol/l, the sensitivity and specificity of UA predicting cardiovascular events were 85% and 98%, the accuracy was 93%, respectively.

  CONCLUSION  Serum uric acid is associated with prognosis in CHF patients. Hyperuricemia is an independent risk factor for patients with heart failure.