Paracrine action of myocardial fibroblast myocytes

Cardiac fibroblasts are key components of normal cardiac functions and the response to stressors and injury. Increasing evidence shows that cardiac fibroblasts play an important role in matrix production and cardiac function including cardiac electrophysiology and contractility. Cardiac fibroblasts interact with myocytes via paracrine mechanism. A better understanding of cardiac fibroblasts may develop into a novel treatment for heart failure.