Neutrophil/lymphocyte ratio, mean platelet volume and high-sensitivity C-reactive protein are associated with types of coronary heart disease and degrees of coronary artery stenosis

AIM:To study the clinical value of neutrophil/lymphocyte ratio (NLR), mean platelet volume (MPV) and high-sensitivity C-reactive protein (hs-CRP) for the types of coronary heart disease and the degrees of coronary artery stenosis. METHODS: Two hundred and twenty patients diagnosed with coronary heart disease based on coronary angiography were selected for the study. Among them, 64 unstable angina (UAP) patients and 76 acute myocardial infarction (AMI) patients were in the experimental group, and 80 stable angina patients were in the control group. White blood cell count, neutrophil count, lymphocyte count, hs-CRP, platelet count and MPV of the two groups were recorded and NLR was calculated. The association among the three indexes (NLR, MPV and hs-CRP) and types of coronary heart disease and degrees of coronary artery stenosis was analyzed. Logistic regression was conducted to probe the diagnostic and prognostic significance of the three indexes. RESULTS: Statistically significant differences were found in NLR, MPV and hs-CRP between experiment group and control group, between unstable angina and acute myocardial infarction, and between degrees of coronary artery stenosis. NLR was found to be a significant factor in predicting the heart function classifications and the all-cause re-hospitalization rates. CONCLUSION: NLR, MPV and hs-CRP have some clinical value for types of coronary heart disease and degrees of coronary artery stenosis, as well as for the prognosis of postoperative PCI patients.