Association between platelet-to-lymphocyte ratio and coronary collateral circulation formation

AIM To investigate the relationship between the platelet-to-lymphocyte ratio (PLR) and the formation of coronary collateral circulation (CCC) in patients with coronary chronic total occlusion (CTO). METHODS This study included 137 patients who underwent coronary angiograph in our hospital and were diagnosed as chronic total occlusion with at least one major coronary artery involved. The Rentrop grade system was utilized to clarify the collateral vessels as poor CCC (Rentrop 0-1) and good CCC (Rentrop 2-3). PLR was calculated according to the results of routine blood test. RESULTS Of the enrolled patients, 57 were graded into the poor CCC group and 80 into the good CCC group. The PLR value was significantly higher in poor CCC group than in good CCC group (163±86 vs. 108±36, P<0.01). Multivariate logistic regression demonstrated that PLR was an independent predictor for poor CCC (OR: 1.02, 95%CI: 1.008-1.032; P<0.01). The ROC curve yielded an under curve area of 0.75 for PLR to predict impaired CCC formation, with PLR value>140.876 indicating a sensitivity of 61% and a specificity of 82% for predicting CCC. CONCLUSION In patients with CTO, PLR is associated with the CCC formation and high PLR level is an independent predictor for poor CCC.