Association of serum irisin level with severity of coronary stenosis in patients with coronary heart disease

AIM To explore the relationship between the serum irisin level and severity of coronary stenosis in patients with coronary heart disease( CHD). METHODS A total of 249 patients diagnosed with CHD in Xijing Hospital were enrolled and divided into stable angina pectoris( SAP),unstable angina pectoris( UAP) and acute myocardial infarction( AMI) groups. Serum irisin levels were detected with ELISA method and subjects were divided into low irisin level group( irisin 2. 3 μg / ml) and high irisin level group( irisin > 2. 3 μg / ml). Correlation between Gensini score and serum irisin level was analyzed. RESULTS Low irisin level group revealed severe coronary stenosis compared with high irisin level group( P < 0. 05,P < 0. 01),the number of stenosed coronary vessels and Gensini score were independent risk factors for serum irisin level and Gensini score was inversely associated with serum irisin level( P < 0. 01). CONCLUSION There was a correlation between Gensini scores and serum irisin levels.