Evaluation and prognosis of impaired cardiac functions in diabetic patients with hyperuricemia by metabolic index combined with cardiac color Doppler echocardiography

  AIM  To investigate the effect of metabolic indexes combined with color Doppler echocardiography on cardiac function impairment and prognosis in diabetic patients with hyperuricemia.

  METHODS  We selected 100 patients with T2DM and 100 patients with T2DM combined with HUA who were diagnosed and treated in the People's Hospital of Chaozhou City, Guangdong Province from February 2019 to September 2021. The general clinical data, metabolic indicators and cardiac indicators between the two groups were analyzed. Multivariate logistic regression analysis was used to find the risk factors in diabetic patients with HUA and complications, and ROC curve was used to analyze the predictive value of metabolic and cardiac indicators for T2DM with HUA

  RESULTS  Compared with those in T2MD group, the T2DM combining with HUA group had significantly higher body mass index (BMI) (P<0.01), systolic blood pressure (SBP) (P<0.01), diastolic blood pressure (DBP) (P<0.05), triglyceride (TG) (P<0.01), low density lipoprotein cholesterol (LDL-C) (P<0.05), creatinine (SCR) (P<0.01), uric acid (UA) (P<0.01), urea nitrogen (BUN) (P<0.01) and urinary albumin/creatinine ratio (UACR) (P<0.01) ,but lower high density lipoprotein cholesterol (HDL-C) (P<0.01). In addition, the T2DM combining with HUA group had significantly higher diastolic ventricular septal thickness (IVST), left ventricular myocardial mass (LVM), left ventricular myocardial mass index (LVMI) and relative wall thickness (RWT) in T2DM combined with Hua group increased significantly (P<0.01), and the left ventricular ejection fraction (LVEF) decreased significantly (P<0.01) compared to those in T2MD. Multivariate logistic regression analysis showed that BMI, TG, SCR, LVEF, LVM and LVMI were independent risk factors for T2DM patients with HUA(P<0.05). ROC curve analysis showed that BMI, SCR, LVEF, LVM and LVMI had diagnostic value for T2DM complicated with HUA (P<0.05). Multivariate Logistic regression analysis showed that BMI, TG, SCr, LVEF, LVM and LVMI were independent risk factors for diabetic albuminuria (P<0.05). TG, UA, SCr and LVM were independent risk factors for diabetic peripheral neuropathy (P<0.05). TG, UA, SCr, LVM and LVMI are independent risk factors for diabetic retinopathy (P<0.05).

  CONCLUSION  Abnormal metabolic indexes such as lipid and renal functions and abnormal cardiac indexes of ventricular hypertrophy are associated with diabetes complicated with HUA and diabetic complications, providing important reference for the diagnosis and treatment of this disease.