Preductive application of three detection in poor prognosis after emergency PCI in patients with acute myocardial infarction

  AIM   To explore the predictive value of homocysteine (Hcy), secreted frizzled related protein 5 (SFRP5) and uric acid (UA) three detection in poor prognosis after emergency PCI in patients with acute myocardial infarction.

  METHODS  Ninety-six patients with acute myocardial infarction treated in Ziyang First People's Hospital from January 2017 to December 2018 were selected, according to 2-year follow-up data, they were divided into the control group (n=63) and the observation group (n=33). The levels of Hcy, SFRP5 and UA in patients with different prognosis were analyzed; Logistic regression was used to analyze the related factors that affected the poor prognosis in the patients; ROC curve was drawn to analyze the predictive value of the three combined (Hcy, SFRP5 and UA) detection for the poor prognosis after PCI.

  RESULTS  ① There was no significant difference in gender, age, body weight, history of hypertension, and history of diabetes between the two groups; there were significant differences in the family history of cardiovascular and cerebrovascular diseases, smoking history, drinking history and coronary artery disease number between the two groups (all P<0.01). ② The levels of Hcy and UA in the observation group were significantly higher than those in the control group and the level of SFRP5 was lower than that in the control group (all P<0.01). ③ Cardiovascular and cerebrovascular family genetic history, smoking history, drinking history, coronary artery disease branch number, Hcy, SFRP5, UA were related risk factors for poor prognosis after PCI in patients with acute myocardial infarction (all P<0.01). The AUC of Hcy, SFRP5 and UA and combined detection of the three was 0.948, 0.894, 0.823 and 0.991,respectively, the sensitivities were 87.56, 85.12, 83.65 and 91.56, respectively, and the specificities were 89.45, 87.26, 84.19 and 92.14, respectively, the AUC, sensitivity and specificity of combined detection were the best.

  CONCLUSION  Hcy, SFRP5 and UA are closely related to the prognosis of patients with acute myocardial infarction after PCI,, and the early combined detection of the three indicators in patients with acute myocardial infarction after PCI is helpful to evaluate the prognosis.