Correlation between serum visfatin, A-FABP and blood pressure variability in elderly patients with hypertension

  AIM  To investigate the correlation between serum visfatin, A-FABP and blood pressure variability in elderly patients with hypertension.

  METHODS  235 elderly patients with hypertension (> 60 years old) admitted to Baoding Second Hospital from January 2017 to February 2019 were selected. Serum visfatin and A-FABP levels were measured by ELISA. The correlation between visfatin and A-FABP and 24-hour mean arterial pressure (24-hour MABP), 24-hour diastolic pressure variability (24-hour DBPV) and 24-hour systolic pressure variability (24-hour SBPV) was analyzed.

  RESULTS  The optimum threshold values of serum visfatin and A-FABP were 43.5 ng/ml and 20.9 ng/ml respectively. The 24-hour MABP, 24-hour DBPV and 24-hour SBPV in the group of visfatin < 43.5 ng/ml were significantly lower than those in the group of visfatin ≥ 43.5 ng/ml (P < 0.01). The 24-hour DBPV, 24-hour SBPV and visfatin in group A-FABP < 20.9 ng/ml were significantly lower than those in group A-FABP ≥ 20.9 ng/ml (P < 0.01). 24 hSBPV was positively correlated with age, LDL-C, serum visfatin and serum A-FABP, and the difference was statistically significant (all P < 0.01). 24 hDBPV was positively correlated with age, serum visfatin and serum A-FABP (all P < 0.01).

  CONCLUSION  Age, A-FABP and visfatin are positively correlated with the increase of BPV, while BPV is closely correlated with target organ damage in elderly patients with hypertension.