Correlation between monocyte to high density lipoprotein cholesterol ratio and the severity of coronary artery stenosis in patients with coronary heart disease and clinical significance

  AIM  To investigate the relationship between monocyte to high density lipoprotein cholesterol ratio (MHR) and severity of coronary artery stenosis in patients with coronary heart disease and its clinical significance.

  METHODS  407 patients who underwent coronary angiography from July 2017 to April 2018 in the second Hospital of Shanxi Medical University were divided into a coronary artery disease group (coronary artery stenosisd ≥ 50%, n = 306) and a control group (coronary artery stenosis < 50%, n = 101). The degree of coronary stenosis was expressed by Gensini score. The clinical data of the two groups were collected and compared. Multivariate Logisitic regression analysis was used to analyze factors affecting degree of coronary artery stenosis. Pearson correlation analysis was used to analyze the correlation between MHR and coronary Gensini score in patients with coronary heart disease and a ROC curve was used to analyze the value of MHR in the diagnosis of coronary heart disease.

  RESULTS  The Gensini score, monocyte count, low density lipoprotein cholesterol, total cholesterol and triglyceride levels in the coronary heart disease group were higher than those in the control group (all P < 0.01) and the level of high density lipoprotein cholesterol was lower than that in the control group (P < 0.01). Multivariate Logisitic regression analysis showed that MHR was an independent factor affecting the degree of coronary artery stenosis (Wald χ² = 10.397, P < 0.01). Pearson correlation analysis showed that there was a significant positive correlation between MHR and coronary Gensini score in patients with coronary heart disease (r = 0.672, P < 0.05). The area under MHR of ROC curve was 0.742 (95%CI: 0.693-0.792). When the MHR cut-off point was 0.35, the diagnostic efficiency reached highest, the sensitivity was 62.7%, the specificity was 77.2% and the accuracy was 73.5%.

  CONCLUSION  MHR is an independent correlation factor of coronary stenosis and can be used as an important reference index for clinical diagnosis of coronary artery disease.