Wei LI, Ming-xin LIU, Yan-hong TANG. Role and research progress of NLRP3 inflammasome in cardiomyopathy and arrhythmias[J]. Chinese Heart Journal, 2019, 31(3): 334-338. DOI: 10.12125/j.chj.201809038
    Citation: Wei LI, Ming-xin LIU, Yan-hong TANG. Role and research progress of NLRP3 inflammasome in cardiomyopathy and arrhythmias[J]. Chinese Heart Journal, 2019, 31(3): 334-338. DOI: 10.12125/j.chj.201809038

    Role and research progress of NLRP3 inflammasome in cardiomyopathy and arrhythmias

    • NLRP3 inflammasome is a participant in the innate immune response that triggers inflammation through a related activation signal. NLRP3 inflammasome is expressed in cardiomyocytes and cardiac fibroblasts, and caspase-1 is generated by procaspase-1 hydrolyzed to promote the maturation and release of IL-1β and IL-18, resulting in cell pyroptosis. Its infiltration affects the development of cardiovascular diseases such as cardiomyopathy and arrhythmia. In this review, we describe the role and related mechanisms of NLRP3 inflammasomes in cardiomyopathy and arrhythmias, which are important in exploring treatment options for NLRP3 inflammasome related diseases.
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