Abstract: AIM:To study the influence of left anterior descending coronary stenting on left ventricular function in patients with coronary heart disease and left ventricular dysfunction. METHODS: One hundred and thirtynine cases of left anterior descending coronary stenosis or occlusion with coronary heart disease and varying degrees of left ventricular dysfunction were randomly divided into two groups: 72 cases of percutaneous coronary intervention (PCI) and 67 cases of simple drug treatment (SDT). Left ventricular enddiastolic diameter (LVEDD), left ventricular endsystolic diameter (LVEDS), left ventricular ejection fraction (LVEF) and NTproBNP were examined before PCI or SDT and 1 and 6 months after PCI or SDT and the results were compared. RESULTS: LVEDD, LVEDS and NTproBNP 6 months after PCI or SDT were significantly lower while LVEF was significantly higher (all P<005) than those before PCI or SDT. LVEDD and LVEDS were significantly lower and LVEF was significantly higher in PCI group (all P<005) than those in SDT group. However, no significant difference was observed in the above parameters when comparison was made before and 1 month after PCI or SDT. CONCLUSION: Left anterior descending artery stenting significantly improves left ventricular function.