陕西汉族PCI术后人群CYP2C19基因多态性分析

Genetic polymorphism analysis of CYP2C19 in Shaanxi Han population after percutaneous coronary intervention

摘要: 目的描述陕西省汉族PCI术后人群的细胞色素2C19(CYP2C19)基因型分布特征。方法采用个体化基因诊断芯片技术对1 220例陕西汉族PCI术后人群进行CYP2C19基因分型检测。结果陕西汉族术后人群中男性野生基因型比例为34.02%（*1*1），突变杂合子基因型比例为33.61%（*1*2和1*3），突变纯合子基因型比例为9.43%（*2*2、*2*3和*3*3）。女性野生基因型比例为9.34%（*1*1），突变杂合子基因型比例为11.23%（*1*2和1*3），突变纯合子基因型比例为2.38%（*2*2、*2*3和*3*3）。结论陕西汉族PCI术后人群CYP2C19基因多态性以野生型纯合子*1*1和突变杂合子*1*2为主。

Abstract: AIM To study the characteristics of CYP2C19 genotype in Shaanxi Han population after percutaneous coronary intervention (PCI) and establish a foundation for individualized treatment. METHODSGenotyping of CYP2C19 in 1 220 Shaanxi Han patients after PCI were determined by gene chip. RESULTSAccording to genotyping results, the frequencies of wild type (WT) *1*1 in Shaanxi Han population were 34.02%, WT *1*2 and *1*3 were 33.61%, and WT *2*2, *2*3 and *3*3 were 9.43% in males. The frequencies of WT *1*1 were 9.34%, WT *1*2 and *1*3 were 11.23%, and WT *2*2, *2*3 and *3*3 were 2.38% in females. CONCLUSIONGenetic polymorphism analysis of CYP2C19 WT *1*1 and *1*2 in Shaanxi Han population after PCI are most frequent.