Rho激酶在心血管疾病中新进展及Rho激酶抑制剂的应用
Rho kinase in cardiovascular diseases and applications for Rho kinase inhibition: Current progress
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摘要: Rho激酶(ROCK)被认为是治疗心血管疾病的新靶点。本文主要简述RhoA/ROCK通路在调节脉管系统的功能,并探讨其在心血管疾病发病中的作用机制。Abstract: Rho kinase (ROCK) is regarded as a novel therapeutic target in the treatment of cardiovascular diseases. In this review we summarize the current understanding of the crucial role of the RhoA/ROCK pathway in the regulation of vascular functions and present its physiological and pathophysiological functions in cardiovascular diseases.autophagy.