田倪妮, 魏 玲, 李宏键, 陈 黔, 陈韦强, 王 欢, 倪茂娥. 心肌热休克蛋白70在慢性心力衰竭患者中的表达[J]. 心脏杂志, 2015, 27(3): 314-317.
    引用本文: 田倪妮, 魏 玲, 李宏键, 陈 黔, 陈韦强, 王 欢, 倪茂娥. 心肌热休克蛋白70在慢性心力衰竭患者中的表达[J]. 心脏杂志, 2015, 27(3): 314-317.
    shu
    Expression of heat shock protein 70 in atrial tissue of patients with chronic heart failure[J]. Chinese Heart Journal, 2015, 27(3): 314-317.
    Citation: Expression of heat shock protein 70 in atrial tissue of patients with chronic heart failure[J]. Chinese Heart Journal, 2015, 27(3): 314-317.
    shu

    心肌热休克蛋白70在慢性心力衰竭患者中的表达

    Expression of heat shock protein 70 in atrial tissue of patients with chronic heart failure

      摘要
    • 摘要: 目的:观察慢性心力衰竭患者心肌热休克蛋白(HSP70)的表达。方法: 60例手术患者分为3组，其中心功能1级组20例，心功能2级组20例，心功能3级组20例。采用实时荧光定量（RT-PCR）方法检测HSP70的mRNA表达量。结果:①与心功能1级患者比较，HSP70 mRNA 水平在心功能2级、心功能3级组的心肌组织中表达明显减少（均P<0.05），且在心功能3级组较心功能2级组明显减少（P<0.05）。②HSP70 mRNA水平与慢性心力衰竭患者年龄、病程呈负相关。结论:慢性心力衰竭患者心肌HSP70的表达减少，可能与HSP70随着心功能恶化其保护作用减弱有关。

       

      Abstract: AIM:To explore the expression of heat shock protein (HSP) 70 in atrial tissue of patients with chronic heart failure (CHF). METHODS: Right atrial tissue was taken from 60 patients undergoing cardiac surgery. Patients were equally divided into NYHA I group, NYHA II group and NYHA III group (n=20, each). mRNA level of HSP70 was detected by real-time fluorescence quantitative PCR method. RESULTS: mRNA level of HSP70 significantly decreased in both NYHA II group and NYHA III group compared with NYHA I group (both P<0.05). mRNA level of HSP70 significantly decreased in NYHA III group compared with NYHA II group (P<0.05). mRNA level of HSP70 was negatively correlated with age and years of disease in CHF patients. CONCLUSIONS: HSP70 expression decreases in CHF patients, indicating that the protective effect of HSP70 weakens with the degree of increasing disease severity.

       

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