Abstract: AIM:To evaluate the safety and effect of one percutaneous coronary intervention (PCI) for three coronary arteries in patients with three-vessel coronary disease. METHODS: According to the inclusion criteria, 52 consecutive patients with three-vessel coronary disease between January 2010 and September 2012 were enrolled in this study. Three coronary arteries were completely treated by one PCI in all patients. Follow-up was conducted in all patients and major adverse cardiac events (MACE: cardiogenic death, myocardial infarction, and repeated revascularization) were calculated. RESULTS: One-time PCI was conducted in 52 patients with 195 target lesions and 156 target vessels treated by PCI, and the success rate was 100%. Mean Syntax Score of the 52 patients was 21. At 32 ± 9 months, the rate of MACE was 2%(1/52) and the secondary point events rate was 6% (3/52). CONCLUSION: One PCI for three coronary arteries is fairly safe and effective in patients with three-vessel coronary disease.