Abstract: AIM: To observe and analyze the effect of essential hypertension (EH) stages and results of blood pressure control on endovascular active substance and blood-lipid level in seniors. METHODS: Sixty elderly, retired subjects aged >80 years were divided into five groups: I-period group, II-period group, III-period group, ideal blood pressure control group and non-ideal blood pressure control group. Radioimmunization was used to measure levels of ADM, ET, ANP and AngII, and nitric acid reductase was used to measure NO. Blood lipid level was tested enzymatically method and with the turbidimetric immunoassay method. RESULTS: AngII of EH I period rose significantly. ADM, ET and ANP of EH II period rose but NO dropped significantly. ADM, ET, ANP, AngII of EH III period rose significantly compared with those of EH II period. NO of EH III period decreased significantly compared with that of I and II periods. NO, ANP and AngII of ideal blood pressure control group were not significantly different from those in the control group, but ADM, NO, ET and ANP in the ideal group were significantly different from those in the non-ideal blood pressure control group. No significant difference was found in blood lipid levels among all groups. CONCLUSION: The level of endovascular active substance can be used as one of the indices to establish clinical stages and evaluate curative effects.