Abstract:
AIM:To determine the plasma copeptin concentration in patients with acute myocardial infarction (AMI) and coronary artery disease (CAD) and to explore its clinical value. METHODS: One hundred and ten patients admitted from January 2010 to December 2010 to our hospital due to chest discomfort were included in the study. Plasma copeptin level was detected using enzyme immunoassay assay and levels of troponin and CK-MB were determined using fixed chromatography immunoassay. RESULTS: Plasma copeptin levels in AMI patients were significantly higher than those in patients with other diseases (P<0.01). In AMI patients, copeptin concentrations decreased with the increasing time of symptoms, whereas TNT CK-MB concentrations increased. Copeptin levels in patients with three-vessel lesions were significantly higher than those in patients with one- or two-vessel lesions. CONCLUSION: Early determination of plasma copeptin level is of important clinical and diagnostic value for suspected AMI patients with subclinical symptoms. Elevated plasma copeptin level may reflect CAD.