Abstract: Chronic heart failure is the end stage of various heart diseases. Despite improvements in diagnosis and therapy, chronic heart failure is a major medical problem in China. The prognosis of chronic heart failure is poor, and the mortality of severe heart failure is as high as 50%. It is of great clinical significance to find specific and sensitive biomarkers for the diagnosis, treatment and prognosis of chronic heart failure. Soluble ST2 has become a hotspot because it is not influenced by factors such as age and weight. Many studies have shown that sST2 is of great clinical significance for diagnosis, prognosis and risk stratification in chronic heart failure.