白介素-10基因1 082G/A多态性与急性冠脉综合征的关联性

Association between interleukin-10 gene 1 082G/A polymorphism and acute coronary syndrome

摘要: 目的:探讨常州地区汉族人群白介素-10（IL-10）基因1 082G/A多态性与急性冠脉综合征(ACS)的关联性。方法： ACS组471例，对照组197例，采用基因测序技术检测基因型，并调查相关因素和测定血脂。结果： IL-10基因1 082G/A中在ACS组和对照组中均存在GG、AG和AA 3种基因型；与对照组相比，3种基因型分布频率、等位基因分布频率均无统计学差异；调整对多个危险因素行多元Logistic回归分析，示IL-10基因1 082G/A 3种基因型与ACS的发病仍无相关性。结论： IL-10基因1 082G/A 多态性与常州地区汉族人群ACS的发病无关联。

Abstract: AIM:To investigate the association between interleukin-10 (IL-10) gene 1 082G/A polymorphism and acute coronary syndrome (ACS) in Chinese Han population of the Changzhou region of Southern Jiangsu. METHODS: Four hundred and seventy-one ACS patients and 197 control subjects were recruited in the study. The polymorphism was genotyped by gene sequencing. RESULTS: GG, AG and AA existed in both ACS group and control group. Compared with those in control group, genotypes and alleles in ACS group showed no statistical differences and multivariate logistic regression analysis also showed no correlation. CONCLUSION: The IL-10 gene polymorphism is not associated with ACS in Chinese Han population of Changzhou region of Southern Jiangsu.