Abstract: AIM:To explore the effect of different doses atorvastatin treatment on the levels of serum hypersensitive C-reactive protein (CRP) and lipid in patients who were in early acute myocardial infarction (AMI). METHODS: A total of 60 patients with AMI who were hospitalized from January 2014 to May 2014 were randomly divided into 20 mg and 40 mg groups with 30 patients in each group. All patients were administered atorvastatin on the basis of conventional treatment after admission, 20 mg and 40 mg, respectively. We compared the effect on the levels of hs-CRP and lipids in patients of both groups upon hospital admission and after treatment for 1 week with different doses of atorvastatin. RESULTS: Levels of serum hs-CRP, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol in the two groups before and after 1 week treatment were decreased significantly, and the level of LDL-C decreased more significantly in the 40 mg group than in the 20 mg group after treatment, with statistically significant differences between groups (P<0.05). CONCLUSION: Atorvastatin therapy may reduce levels of serum hs-CRP and lipid effectively in early AMI patients (within 1 week), and the reduction of LDL-C in the 40 mg group is more significant than in the 20 mg group.