Abstract: AIM To evaluate the cardioprotection of ischemic postcondition for patients with acute myocardial infarction during percutaneous coronary intervention. METHODS A total of 105 patients with AMI were enrolled the study, 54 patients were in ischemic postconditioning (PC) group and 51 patients in non-ischemic postconditioning (NPC) group. The level of plasma CK and CK-MB was detected and the indices of left ventricular end diastolic volume index, left ventricular end systolic volume index and left ventricular ejection fraction were measured by ultrasonic cardiogram after the onset of AMI. Malignant arrhythmia, angina occurred after AMI and death rate in hospital were compared between the two groups. RESULTS The peak level of plasma CK and CK-MB were higer in NPC group compared with those in PC group (P<0.05). The parameters of cardiac performance decreased significantly in PC group compared with those in NPC group. Significant difference was found in left ventricular end diastolic volume index ［（64±6）ml/m2 vs （67±6 ）ml/m2, P<0.05］, left ventricular end systolic volume index ［(30±4)ml/m2 vs （34±4）ml/m2, P<0.05］ and left ventricular ejection fraction (0.53±0.02 vs 0.50±0.03, P<0.05) in PC group 3 months after PCI. The incidence of malignant arrhythmia and angina after AMI were lower in PC group compared with that in NPC group (P<0.05) while the difference in the death rate in hospital was not significant between the two groups. CONCLUSION Ischemic postcondition has some cardioprotection for patients with acute myocardial infarction during percutaneous coronary intervention.