Abstract: Atrial fibrillation (AF) is a most common type of tachycardia caused by atrial re-entrant circuits and small re-entrant circuits. Inflammation plays a role in the pathophysiology of AF and adhesion molecules are an early inflammatory response modulator (including integrin), which serves as the signal transduction factor and activates signal transduction pathways, including mitogen-activated protein kinases and focal adhesion kinase. Collagen cells will then secrete more collagen. Atrial myocardial fibrosis may be associated with increasing collagen. Studies of the relationship of integrin and atrial myocardial fibrosis will show the mechanism of myocardial fibrosis and thus reduce the incidence of AF.