Abstract: Ca2+, calmodulin (CaM) and sympathetic nerves (SN) play an important role on the pathophysiological changes of the vascular system and the effect of acupoints. By systematically analyzing the effect of Ca2+CaM on myocardial activity and on ischemia, the conductive effect of Ca2+CaM on drugs that intervene in cardiovascular functions of Ca2+CaM and SN on the correlation between the channel points and zangfu organs, intervention of SN on the correlation between the channel points and zangfu organs, the effect of SN on the pathophysiological changes of the vascular system, correlation between CaM and sympathetic nerves, mechanism of Ca2+CaM and sympathetic nerves in the effect of heart and channel acupoints, it has been found that Ca2+CaM and the sympathetic nerves are closely related to the heart and channel acupoints. At present, few people pay close attention to the mechanisms of Ca2+CaM and SN in the correlation between the heart and acupoints. Therefore, our survey of the correlation between the heart and acupoints based on calmodulin and sympathetic nerves will open a new perspective for theoretical research. It is worthwhile to further investigate into channel points.