Abstract:
AIM To investigate the correlation between circadian rhythm of blood pressure after percutaneous coronary intervention (PCI) and major adverse cardiovascular events (MACE) in patients with ST segment elevation myocardial infarction (STEMI).
METHODS Clinical data of STEMI patients in the Department of Cardiology, Xi’an People’s Hospital were collected from June 2019 to December 2020, with a total of 112 cases. According to the nocturnal blood pressure drop rate (NBPDR) on the first day after PCI, the patients were divided into dipper group, non-dipper group, super-dipper group and reverse dipper group, and the patients were followed up for an average of 1.5 years. Univariate Kaplan-Meier regression and multivariate Cox regression models were used to compare the correlation between baseline data and MACE of the four groups.
RESULTS Compared with the dipper group, the non-dipper group (P<0.05) and reverse-dipper group (P<0.01) had an increasing risk of MACE. Subgroup analysis showed that female patients in the non-dipper group, patients over 65 years old in the reverse-dipper group and patients younger than 65 years old in the super-dipper group had an increasing risk of MACE (P<0.05), while patients with severe coronary artery disease in the reverse-dipper group had a higher risk of MACE (P<0.05). Additionally, the RCS curve showed that MACE risk was the lowest when NBPDR was equal to 17.05%.
CONCLUSION Blood pressure circadian rhythm is closely related to the recurrence of MACE in STEMI patients after PCI.
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