陈晋玉, 王南丁, 周纳纳, 韩茹, 雷瑗琳. IL - 18在动脉粥样硬化相关疾病中的研究进展[J]. 心脏杂志, 2023, 35(2): 208-212. DOI: 10.12125/j.chj.202202033
    引用本文: 陈晋玉, 王南丁, 周纳纳, 韩茹, 雷瑗琳. IL - 18在动脉粥样硬化相关疾病中的研究进展[J]. 心脏杂志, 2023, 35(2): 208-212. DOI: 10.12125/j.chj.202202033
    Jin-yu CHEN, Nan-ding WANG, Na-na ZHOU, Ru HAN, Yuan-lin LEI. Research progress of IL-18 in atherosclerotic diseases[J]. Chinese Heart Journal, 2023, 35(2): 208-212. DOI: 10.12125/j.chj.202202033
    Citation: Jin-yu CHEN, Nan-ding WANG, Na-na ZHOU, Ru HAN, Yuan-lin LEI. Research progress of IL-18 in atherosclerotic diseases[J]. Chinese Heart Journal, 2023, 35(2): 208-212. DOI: 10.12125/j.chj.202202033

    IL - 18在动脉粥样硬化相关疾病中的研究进展

    Research progress of IL-18 in atherosclerotic diseases

    • 摘要: 动脉粥样硬化(atherosclerosis,AS)是心血管系统的慢性炎症性疾病,是缺血性心脏病、脑卒中和周围血管疾病的主要病因之一。越来越多的证据表明,炎症反应是斑块不稳定性及斑块破裂的重要因素,贯穿不稳定斑块的发生、发展及破裂的全过程。白细胞介素18(interleukin-18,IL-18)是一种新型的促炎细胞因子,可以促进炎症反应,是参与动脉粥样硬化炎症进程的重要因子。本文就IL-18在AS发病机制中的作用及其在AS相关疾病中的研究现状作一综述,以期为AS及其相关疾病提供新的检测指标和治疗靶点。

       

      Abstract: Atherosclerosis (AS) is a chronic inflammatory disease of the cardiovascular system and one of the main causes of ischemic heart disease, stroke and peripheral vascular disease. More and more evidences indicate that inflammatory response is an important factor of plaque instability and plaque rupture, which runs through the whole process of the occurrence, development and rupture of unstable plaques. Interleukin-18 is a new type of proinflammatory cytokine, which can promote inflammatory response and is an important factor involved in the inflammatory process of atherosclerosis. This paper reviews the role of interleukin-18 in the pathogenesis of atherosclerosis and its current research status in AS-related diseases to provide new detection indicators and therapeutic targets for atherosclerosis.

       

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