Abstract: The incidence of patent foramen ovale (PFO) is high, and PFO is present in approximately one-quarter of adults. As the results of randomized controlled trials comparing transcatheter PFO closure and drug therapy have been updated, countries have successively updated PFO guidelines or consensus. China′s recommendation for PFO treatment only stays on the 2017 “Chinese expert consensus on preventive closure of patent foramen ovale”. In view of the large population of PFO, in order to standardize the clinical application of PFO closure, we learnt from the latest research at domestic and abroad, combined with the specific situation of China, experts in this field have developed a Chinese expert guidelines for the prevention of patent foramen ovale-associated stroke for reference.