Abstract:
AIM To study risk factors of patients with premature coronary heart disease and to investigate the correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance.
METHODS 93 patients underwent coronary angiography were divided into premature coronary heart disease group (n=63) and a control group (coronary artery stenosis <50%, n=30). The Lp-PLA2 levels were investigated between the two groups and the relationship of Lp-PLA2 with risk of patients was studied.
RESULTS Lp-PLA2 levels were significantly higher in premature coronary heart disease group than in the control group(P<0.05). Lp-PLA2 had a significant correlation with Gensini score (r=0.368,P<0.05) and GRACE risk score (r=0.402,P<0.05). Multivariate logistic regression analysis showed that Lp-PLA2 was independently associated with premature coronary heart disease (P<0.05).
CONCLUSION Lp-PLA2 is independently associated with premature coronary heart disease and positively related with the severity of coronary artery and prognosis. Thus Lp-PLA2 can be used as a predictor of risk assessment in premature coronary heart disease patients.