何金, 鲁孝楠, 姚璐, 赵家, 李静, 拓胜军, 刘丽文. 肥厚型心肌病患者的生活质量及其影响因素[J]. 心脏杂志, 2022, 34(3): 310-315. DOI: 10.12125/j.chj.202112115
    引用本文: 何金, 鲁孝楠, 姚璐, 赵家, 李静, 拓胜军, 刘丽文. 肥厚型心肌病患者的生活质量及其影响因素[J]. 心脏杂志, 2022, 34(3): 310-315. DOI: 10.12125/j.chj.202112115
    Jin HE, Xiao-nan LU, Lu YAO, Jia ZHAO, Jing LI, Sheng-jun TA, Li-wen LIU. Quality of life and influencing factors in patients with hypertrophic cardiomyopathy[J]. Chinese Heart Journal, 2022, 34(3): 310-315. DOI: 10.12125/j.chj.202112115
    Citation: Jin HE, Xiao-nan LU, Lu YAO, Jia ZHAO, Jing LI, Sheng-jun TA, Li-wen LIU. Quality of life and influencing factors in patients with hypertrophic cardiomyopathy[J]. Chinese Heart Journal, 2022, 34(3): 310-315. DOI: 10.12125/j.chj.202112115

    肥厚型心肌病患者的生活质量及其影响因素

    Quality of life and influencing factors in patients with hypertrophic cardiomyopathy

    • 摘要:
        目的   研究肥厚型心肌病(hypertrophic cardiomyopathy,HCM)患者的生活质量及其影响因素,为综合防治提供依据。
        方法   连续纳入 150例HCM 患者,同期选取150例年龄和性别匹配的健康对照者,采用36 条目健康调查简表(36-item short-form health survey,SF-36)评估患者的生活质量,同时收集患者的临床资料及超声心动图指标,然后通过多元线性回归分析其影响因素。
        结果   HCM患者在SF-36的生理功能、生理职能、躯体疼痛、一般健康状况、精力、社会功能、情感职能和精神健康这8个维度的得分以及生理健康总分、心理健康总分均显著低于正常对照组(P<0.05)。多元线性回归分析显示,年龄≥65岁(β=−0.153,P<0.05)、女性(β=−0.130,P<0.05)、NYHA心功能分级Ⅲ~Ⅳ级(β=−0.213,P<0.01)、左室流出道梗阻(β=−0.418,P<0.01)、合并其它疾病(β=−0.174,P<0.01)、抑郁(β=−0.389,P<0.01)和焦虑(β=−0.176,P<0.05)是HCM患者生活质量下降的独立危险因素。
        结论   HCM患者的生活质量全面受损,与人口学因素、临床特征和情绪障碍密切相关。因此,要提高 HCM 患者的生活质量,除了解除左室流出道梗阻、积极治疗合并疾病外,还应根据患者的具体情况有针对性地开展健康教育和心理干预。

       

      Abstract:
        AIM   To investigate the quality of life (QOL) and its influencing factors in patients with hypertrophic cardiomyopathy (HCM), and provide evidence for improving the QOL of HCM patients.
        METHODS   A total of 150 HCM patients were consecutively enrolled as subjects, and 150 healthy volunteers matched with age and sex were selected as control group. The QOL was measured with 36-item short-form Health Survey (SF-36), while clinical data and echocardiographic indicators were collected at the same time, and the influencing factors were further analyzed.
        RESULTS  The score of every domain and component summary in SF-36 for HCM patients was lower than control group (P<0.05). Further analysis showed that age ≥65 years (β=−0.153, P<0.05), female gender (β=−0.130, P<0.05), New York Heart Association (NYHA) functional class Ⅲ~Ⅳ (β=−0.213, P<0.01), left ventricular outflow tract obstruction (LVOTO) (β=−0.418, P<0.01), comorbidity (β=−0.174, P<0.01), depression (β=−0.389, P<0.01) and anxiety (β=−0.176, P<0.05) were independent risk factors in HCM patients.
        CONCLUSION  The QOL of HCM patients decrease in all dimensions, which is closely related to demographic factors, clinical features and emotional disorders. Therefore, in order to improve the QOL of HCM patients, health education and psychological intervention should be carried out according to the specific situation, in addition to relieving LVOTO and treating concomitant diseases.

       

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