马晨越, 柴萌, 张海涛. IL-37抑制血管钙化相关机制的研究现状[J]. 心脏杂志, 2022, 34(3): 352-355. DOI: 10.12125/j.chj.202107017
    引用本文: 马晨越, 柴萌, 张海涛. IL-37抑制血管钙化相关机制的研究现状[J]. 心脏杂志, 2022, 34(3): 352-355. DOI: 10.12125/j.chj.202107017
    Chen-yue MA, Meng CHAI, Hai-tao ZHANG. Current research on mechanism of IL-37 inhibiting calcification[J]. Chinese Heart Journal, 2022, 34(3): 352-355. DOI: 10.12125/j.chj.202107017
    Citation: Chen-yue MA, Meng CHAI, Hai-tao ZHANG. Current research on mechanism of IL-37 inhibiting calcification[J]. Chinese Heart Journal, 2022, 34(3): 352-355. DOI: 10.12125/j.chj.202107017

    IL-37抑制血管钙化相关机制的研究现状

    Current research on mechanism of IL-37 inhibiting calcification

    • 摘要: IL-37作为一种新型抗炎因子近年来被认为对血管钙化及动脉粥样硬化具有保护作用,在其他钙化反应如瓣膜钙化也发挥有利作用。IL-37可抑制炎症反应和自身免疫反应,并且显示出对成骨细胞分化也有一定的效果。IL-37或可作为一个新型靶点,减缓甚至治疗血管钙化相关心血管疾病。现对IL-37抑制钙化的具体机制作一综述。

       

      Abstract: IL-37, a novel anti-inflammatory factor, has recently been shown to protect against vascular calcification and arteriosclerosis, as well as other calcification reactions such as valve calcification. IL-37 can inhibit the inflammatory reaction and the autoimmune reaction, and it also has some effect on the differentiation of osteoblasts. IL-37 may be a new target to slow down or even treat vascular calcification-related cardiovascular diseases. This article reviews the specific mechanism of IL-37 inhibiting calcification.

       

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