Abstract: Coronary heart disease (CHD) is a global disease with high mortality that affects human life and health. At present, percutaneous coronary intervention (PCI) is a common method for the treatment of CHD in China. But the exploration of the pathogenesis of coronary heart disease and the effective prevention and treatment of CHD has remained a hot research topic in clinical research. In recent years, a large number of studies have shown the correlation between intestinal microecology and coronary heart disease, and the theory of “heart and spleen correlation” in Chinese medicine coincides with modern research results. The relationship between intestinal microecology and coronary heart disease has become a breakthrough in the prevention and treatment of coronary heart disease and the Chinese medicine based on the theory of the heart and spleen may play an important role in it. Based on this theory, this paper aims to explore the relationship between intestinal flora and coronary heart disease, the influence of traditional Chinese medicine on intestinal microecology and the possible intervention methods for coronary heart disease.