AIM  To investigate the effect of metoprolol on early recurrence after radiofrequency ablation of paroxysmal atrial fibrillation.

  METHODS  A total of 100 patients with paroxysmal atrial fibrillation admitted to the Department of Cardiology, First People's Hospital of Jining City from October 2017 to May 2019 were enrolled. The patients were divided into observation group and control group by random number table, 48 patients in the observation group and 52 patients in the control group. Radiofrequency ablation was performed in both groups. The control group was treated with conventional amiodarone. The observation group was combined with metoprolol sustained-release tablets. The serum inflammatory factors, cardiac function indexes, adverse reactions and prognosis of the two groups were compared. Both groups were treated for 3 months.

  RESULTS  The early recurrence rate of the observation group was 4, and the early recurrence rate of the control group was 14%. The difference between the two groups was statistically significant (P < 0.05).CRP、IL-6、TNF-α levels and LAD values in two groups after 1 month and 3 months after radiofrequency ablation showed a downward trend, and the LVEF value showed an upward trend. The difference between the observation group and the control group was statistically significant (P < 0.05, P < 0.01). The preoperative,1 month after operation and 3 month after operation follow-up. The quality of life was assessed by SF-36. The physical health score (PCS) and mental health score (MCS) were significantly improved in the control group and the observation group within 3 months after surgery, but there was no significant difference between two groups.

  CONCLUSION  Metoprolol sustained-release tablets combined with amiodarone reduces the early recurrence rate after radiofrequency ablation of paroxysmal atrial fibrillation, and the effect is better than that of amiodarone alone.