Abstract: Endothelial progenitor cells were first discovered in peripheral blood. With increasing research on endothelial progenitor cells, it was found that endothelial progenitor cells also participate in the process of angiogenesis by releasing exosomes. In diseases such as ischemia-reperfusion injury, microRNA molecules in the exosomes derived from endothelial progenitor cells promote angiogenesis, which can reduce the risk of injury caused by ischemia and hypoxia microenvironment, and promote tissue regeneration and repair. Therefore, endothelial progenitor derived exosomes have been regarded as an important factor in angiogenesis. In this review, recent advances in the role of endothelial progenitor derived exosomes in angiogenesis are reviewed in order to shed a light on the treatment of these diseases such as vascular injury.