Abstract: Acute ST-segment elevation myocardial infarction(STEMI) result from plaque rupture or erosion leading to local thromhus formation with consecutive necrosis of myocytes due to ischemia, which is Caused a series of serious cardiovascular adverse events.At present, studies have shown that soluble tumor necrosis factor-like weak inducer of apoptosis(sTWEAK), matrix metalloproteinase-9 (MMP-9)and other inflammatory factors may be risk factors for STEMI, and even help clinicians diagnose, treat and judge prognosis. Therefore, the clinician is thinking about combining multiple inflammatory factors to assess the risk of patients with STEMI, and provides a broader idea for clinical work. This article reviews the current status of the development, diagnosis and prognosis of sTWEAK and MMP-9 in STEMI.